Keratosis Pilaris Research sign now

We, the undersigned, request that professionals in the field of dermatological research make a better effort to understand and treat a disfiguring skin disease called keratosis pilaris (KP).

Keratosis pilaris usually takes the form of red bumps on the back of peoples upper arms or on the front of their thighs, but in a significant number of cases, the entire body is involved. Many of us have red bumps covering our arms and forearms, our legs (including our lower legs), our backs, our stomachs, our chests, our buttocks in short, everywhere but our hands and feet. There is even a form of keratosis pilaris called keratosis pilaris rubra faceii that affects the face.

Our experience with dermatologists is disappointing. Most of them just try to convince us that the disease is no big deal. They give us ineffective (and very expensive) creams and lotions that have little to no effect. (Typical treatments include AmLactin, LacHydrin, Sulphur Soap, Urea, Salicylic Acid, glycolic acid.) In his online article on KP, Mark A. Crow expressed the attitude of most dermatologists: Treatment in most cases requires simple reassurance and general skin care recommendations.

Unfortunately, those of us who suffer from KP are not easily reassured. We understand that the disease is not life-threatening, but many of us feel that it is life-ruining. KP wreaks havoc with our self-esteem and can lead to depression and intense psychological distress especially for those of us who have widespread cases.

The following comments are from the website, a forum on which KP sufferers share information about their experiences with the disease. These comments show just how emotionally devastating KP can be:

"I am so very upset more than ever. I need something that works that will get rid of these unsightly bumps and get rid of the redness...I get so depressed since I have not many friends and I need confidence badly and this just brings me down. I even cry all the time over it. . . . I dont want to go through another winter being depressed and shady all the time..."

"It is once again approaching summer and the KP is coming back as the target of my depression. I have never met anyone with as bad a case as mine. It would be nice to hear from someone that can relate to some of this. I am 37, and am fairly successful economically and educationally, but not emotionally. I have a degree, a career, a wonderful family, even a farm with lots of critters, but none of it can keep me away from the constant depression because of what I look like, and what measures I have gone through to hide it. I have not worn short sleeves or shorts publicly in over 10 years. I look like a dope junky or someone who survived a porcupine attack!!"

"I turned 32 last month and I've had a severe case of KP my whole life. It pretty much covers my entire arms, legs and butt area. . . . . I haven't worn shorts in a long time either, probably around 17 years or so. I actually don't even own a pair because what is the point? Also, the last time I went swimming I was 17 years old. I wear pants all summer long in extremely hot, humid weather and it just kills me. The comments and questions never stop, and of course I never tell anyone the real reason why I am always covered up. Even my closest friend that I've had for the last 10 years who was my roommate for a year and a half has no idea. I've just led her to believe that I cover up because I'm uncomfortable with my body, which I guess is the truth in a way, but just not in the way she probably assumed. And yes, it is VERY depressing, especially during the summer months when all the "normal" people are out wearing shorts and tank tops having fun in the sun. This f'ing thing has haunted me my whole life and I've pretty much let it take over every area relationships (ha!), socializing, my self esteem you name it and I've got a problem with it."

The causes of KP are poorly understood. As Mark Crows article says, Etiology is unknown, although it may be due to a disorder of corneocyte adhesion that prevents normal desquamation in the area around the follicle. We would like to see more research into the etiology of KP. If this skin disorder were better understood, more effective treatments might be possible.

Recent technological advances make such research feasible. The human genome has been mapped, and sophisticated computer models are available that could analyze any data that researchers could gather about KP. We believe that it is possible to better understand KP but that dermatological researchers have little interest in this illness because they dont believe it to be a serious problem.

For those of us who suffer from it, it is a serious problem. Of course, it is not as serious as problems that are life-threatening, but it is at least as serious as other primarily cosmetic skin disorders. There is even research being done now on how to undo the effects of aging on the skin. Last year, an article in the Dermatological Times reported that genomics researchers had discovered a photomodulation treatment [that] alters the activity of a number of genes involved in signaling pathways for UV-induced inflammatory responses and skin aging . . . . If it is possible to alter the activity of genes involved in aging the skin, then surely it is also possible to alter the activity of any genes involved in the overproduction of keratin in KP sufferers. And if it is worthwhile to undo the effects of aging, it is also worthwhile to relieve the suffering of people with KP.

Researchers should also consider the possible financial rewards of discovering more effective treatments for KP. Since, by many estimates, half the worlds population is affected by KP, the profits from more effective treatments would be enormous. KP sufferers already shell out enormous sums for treatments that dont work. Most of us stop using the treatments after a while because they are so expensive and so ineffective. But we would be willing to continually spend a great deal of money on any treatment that really worked. We urge you to make an effort to find one.

Thank you for your attention to our petition.

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1001 / 5000

Latest Signatures

  • 28 January 20181001. Jomar Lescano (unverified)
    I support this petition
  • 05 November 20171000. Terryann Floyd (unverified)
    I support this petition
  • 10 March 2016999. Candace R
    I support this petition
  • 07 March 2016998. Faye O
    I support this petition
  • 05 March 2016997. Silviaw Mcmahon
    a cure that works will raise many peoples self esteem...including mine
  • 26 February 2016996. Elizabeth K
    I have battled with this. My Keratosis Perlaris is on my arms, and comes up very angry. Sometimes they flare up so badly, they are pus-like and I used to squeeze them as I didn't know what they were and because they fustrated me, so I'd make them even red
  • 14 February 2016995. Matt King
    This condition ruins peoples lives.
  • 11 February 2016994. Shaana K
    Thank you!
  • 11 February 2016993. Jami Guerrero
    I support this petition
  • 04 February 2016992. Mamadshah Terrell
    Capital One Credit Card (a href="")Forex Trading(/a) (br)
  • 03 February 2016991. Matthew C
    I support this petition
  • 02 February 2016990. Frances W
    This is more than a cosmetic issue for many of us, and far more prevalant than people realize.
  • 02 February 2016989. Jessica T
    I support this petition
  • 28 January 2016988. Joanna O
    I have tried numerous cream and oils and they dont seem to work...mine has worsened as i have got older! More research should be put into this!
  • 24 January 2016987. Micha Townsend
  • 23 January 2016986. Stephanie Ortiz
    As a teenager in high school, you have no idea how much this condition has lowered my self esteem. I have missed numerous grad trips and anything that involves showing my skin because I dont want to get made fun of. This is a serious condition and extensi
  • 17 January 2016985. Jacqui P
    I want to find a cure for KP!
  • 16 January 2016984. Cathy K
    I support this petition
  • 09 January 2016983. Melody B
    I support this petition
  • 09 January 2016982. Celestia K
    I have had this my whole life and now it is getting worse after I had a baby please find a treatment that works and help all of us that suffer.
  • 08 January 2016981. Sarah M
    I support this petition
  • 06 January 2016980. Samantha S
    I support this petition
  • 21 December 2015979. Katie F
    I support this petition
  • 21 December 2015978. Kristin S
    I support this petition
  • 20 December 2015977. Hamish C
    I support this petition
  • 19 December 2015976. Anna M
    I support this petition
  • 19 December 2015975. Jessica P
    help us

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Rebecca MendozaBy:
City LifeIn:
Petition target:
American Academy of Dermatology; Charterhouse Therapeutics; Connetics; Enhance Biotech, Inc.; SoleRx, LLC; Molecular SkinCare Limited; Neutrogena; Medicis Pharmaceutical Corporation; Miravant Medical Technologies; Serono;; Barrier Therapeutics; AG


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